Effect of Different Injection Speeds for Spinal Anaesthesia in Caesarean Section

Injection Speed of Spinal Anaesthesia for Asian Women Undergoing Lower Segmental Caesarean Section and the Incidence of Hypotension and/or Use of Vasopressors

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02275897

Enrollment

Registered

2014-10-27

Start date

2013-03-31

Completion date

2014-11-30

Last updated

2014-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effects of; Anesthesia, Spinal and Epidural; in Pregnancy, Pregnancy

Keywords

Lower Segmental Caesarean Section (LSCS), Speed of Injection, Spinal Anaesthesia, Anesthesia

Brief summary

The purpose of this study is to investigate if prolonging the speed of injection during spinal anaesthesia can reduce the incidence of hypotension and/or medication requirements thereby making it safer for the mother and foetus.

Detailed description

We plan to investigate if by varying the speed of injection during spinal anaesthesia, will there be a difference in the incidence of hypotension. Hypotension is a common complication especially for pregnant women undergoing caesarean section. A high speed of injection can theoretically cause a higher spread of anaesthetic, which may increase the incidence of hypotension. We want to know if by prolonging the injection time, will this lead to a reduction in a rate of hypotension.

Interventions

PROCEDUREFast Speed of spinal injection

Speed of injection over 15 seconds

PROCEDURESlow Speed of spinal injection

Speed of injection over 60 seconds

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* at least 18 years of age * singleton term pregnancy * American Society of Anesthesiologists (ASA) class I-II

Exclusion criteria

* Severe pre-eclampsia * contraindications to spinal anaesthesia * Height \<150cm or \>180cm * Weight ≥100kg * Baseline systolic BP \<90 mmHg * Baseline systolic BP \>150mmHg * Category 1 urgency for delivery

Design outcomes

Primary

Measure	Time frame	Description
Incidence of Hypotension	First 10 minutes after injection	How many patients will experience a drop in systolic Blood Pressure of greater than 20%

Secondary

Measure	Time frame	Description
Use of vasoconstrictors	First 10 minutes after injection	—
Adequacy of block	Time of surgery	To determine if the anaesthetic is adequate for the surgery (no pain or movement experienced around the surgical field)

Countries

Malaysia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026