Lung Cancer
Conditions
Keywords
Dexamethasone, Quality of recovery questionnaire, QoR-40, Lung cancer, Video-assisted thoracoscopic
Brief summary
The proposed study is a randomized, double-blind, placebo-controlled evaluation if a small dose of IV dexamethasone during induction anesthesia in association to pre and postoperative intercostal nerve block, improves quality of recovery of thoracoscopic lung resection patients.
Detailed description
This is a study composed by 2 groups of 50 patients undergoing VATS for lung cancer. All subjets will receive intraoperative intercostal nerve block with a maximum dose of 2 mg/kg of bupivacaine with epinephrine 1:200.000 at the beginning and at the end of procedure. The control group will receive a bolus dose of dexamethasone (0.1 mg/kg) and the placebo group saline solution. The study drug or placebo will be administered at the time of anesthetic induction (approximately 30 minutes before surgical incision). Patients will be evaluated daily with the quality of recovery questionary, visual analogue pain and portable spirometry. And, the patients will have pulmonary lung function assessed by portable spirometry.
Interventions
DRUGDexamethasone IV
It will be administered at the induction of the anesthesia
DRUGSaline solution
Sponsors
Laval University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* resectable stage I and II lung cancer patients submitted to VATS * american society of anesthesiology Classification (ASA) I or II
Exclusion criteria
* chronic pain; * chronic analgesic consumption; * severe renal or liver disease; * endocrine or mental diseases; * poorly controlled diabetes; * allergy to bupivacaine; * previous thoracotomy; * systemic use of corticosteroids; * morbid obesity; * poor French comprehension precluding completion of the QoR-40 questionnaire; * patient refusal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study will be postoperative quality of recovery measured by postoperative quality of recovery score 40 (QoR-40) global score. | During the hospital stay and 1 year later |
Secondary
| Measure | Time frame |
|---|---|
| Time of analgesia between the final intercostal nerve block and the first patient-controlled analgesia (PCA) request; | During the hospital stay and 1 year later |
Other
| Measure | Time frame |
|---|---|
| Correlation between pain with visual analog scale and lung function through spirometry test with forced expiratory volume at one second (FEV1) and diffusion capacity (DLCO) | During the hospital stay and 1 year later |
| Total opioid dose consumption in each group | During the hospital stay and 1 year later |
| Side-effect of dexamethasone in the stress response to surgery | During the hospital stay and 1 year later |
Countries
Canada
Outcome results
None listed