Diabetes Complications, Diabetes Mellitus, Type 1
Conditions
Keywords
Children, Cholesterol
Brief summary
Patients with type 1 diabetes type 1 (DM1) have increased risk of death due to heart disease and stroke. These cardiovascular conditions (CVD) are the leading cause of death in patients with DM1 younger than 40 years of age and up to 35% of all persons with DM1 will die before age 55 from CVD. Strategies are needed to help identify adolescents with DM1 at risk for CVD so that interventions to prevent heart disease and stroke can be undertaken.
Detailed description
Patients with type 1 diabetes and healthy controls will have evaluation of their lipid profile. Arterial stiffness, heart rate variability and adiposity measurements will be done in patients with type 1 diabetes and healthy controls. Blood pressure and heart rate will be recorded. 50 ml of urine will be collected from patients and controls. All studies will be performed as a single outpatient visit at Georgetown University.
Interventions
None listed
Sponsors
Howard University
Georgetown University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
12 Years to 21 Years
Healthy volunteers
Yes
Inclusion criteria
Diabetes type 1 or Healthy
Exclusion criteria
Taking medications that lower cholesterol Duration of type 1 diabetes \< 1 year.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| small LDL particles | This is an observational cross sectional study. Samples will be collected through study completion, on average of 6 years duration. | Blood test, based on NMR |
Countries
United States
Contacts
Primary ContactEvgenia Gourgari, MD
Backup ContactKathryn Turner
Outcome results
None listed