Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine

Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine;Randomized Controlled Trial.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02274974

Enrollment

160

Registered

2014-10-27

Start date

2014-08-31

Completion date

2015-04-30

Last updated

2015-06-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Postoperative

Keywords

incisional, infiltration, cs, lidocaine, epinephrine, Adverse Reaction to Topical or Infiltrative Lidocaine

Brief summary

Study to compare between efficacy of post-caesarean section infiltration with lidocaine and epinephrine versus lidocaine only to reduce post-incisional pain.

Detailed description

assessment of adding of epinephrine to lidocaine as local infiltrator to post-caesarean section wound in prolongation of its anaesthetic effect.

Interventions

DRUGLidocaine

•The wound of C.Swill be infiltrated before closure of the skin, with 20 ml of 2% lidocaine.

DRUGlidocaine and Epinephrine

The wound of C.S will be infiltrated before closure of the skin, with 20 ml of 2% lidocaine and epinephrine in related dose manner 1:200.000.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 38 Years

Healthy volunteers

Yes

Inclusion criteria

* Women undergoing caesarean delivery under General anesthesia for various indications. * Women refuse spinal anesthesia.

Exclusion criteria

* Known or suspected sensitivity to local anesthesia. * Medical disorders induced by pregnancy (Pre-eclamptic toxemia, gestational diabetes mellitus, Hepatic diseases, homeostatic disorder) * Medical disorders aggravated by pregnancy (cardiovascular disease, pulmonary disease, renal disease, neurological disease, metabolic or infectious diseases). * Women who hemo-dynamically unstable. * Lack of adequate verbal communication.

Design outcomes

Primary

Measure	Time frame
Timing of first analgesic request.	24 hours

Secondary

Measure	Time frame	Description
Onset of breast breastfeeding	24 hours	—
Onset of mobilization	24 hours	first time patient start moving after the section
Duration of cesarean section	30 min to 90 min	—
Side effects of local infiltration of lidocaine and epinephrine	7 days	—
Postoperative pyrexia	24 hours	\<38°c
Duration of hospital stay	24 hours to 48 hours	—

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026