Pulmonary Disease, Chronic Obstructive
Conditions
Keywords
oxygen therapy, COPD, exercise
Brief summary
The purpose of this study is analyzed the impact of oxygen adjusted during exercise in COPD patients without conventional for LTOT but with exercise desaturation.
Detailed description
Oxygen will be administered through nasal cannulae. Patients will be provided with a tank of liquid oxygen and a rechargeable portable device. The 6 minuts walking test will be used to adjusted oxygen flow in the GFA group (to achieve a mean SpO2 ≥ 90%). In the control group (GC), a 3L/min oxygen flow will be administer. Oxygen is used when the patient perform physical activity. The treatment period for each patient is 6 months (3 months in the GC grup, 3 months in the GFA one).
Interventions
DRUGoxygen
Oxygen administered after adjustment during a waking test or at 3L/min
Sponsors
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Hospital Mutua de Terrassa
Hospital Dos de Maig
Hospital Universitari Sant Joan de Reus
Jtarrega
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical stable moderate to severe COPD (FEV1 \<70%, FEV 1 / FVC \<70%) total lung capacity (TLC\> 80%) without conventional criteria for LTOT, optimal medical therapy, mean SpO2 ≤ 88% during the 6 minuts walking test and active life outside the home, other than active smoking or are in program respiratory rehabilitation.
Exclusion criteria
* Current smokers - Presence of respiratory failure and criteria for LTOT (PO2 \<55 mmHg or 55-60 mmHg associated with pulmonary arterial hypertension, chronic cor pulmonale, congestive heart failure, arrhythmias or polycythemia). - Presence of impaired mobility - Cognitive impairment or intellectual disability to fill in questionnaires - No acceptance of liquid oxygen - Presence of active comorbidities (cardiovascular disease, rheumatologic, renal, hepatic) - Participation in pulmonary rehabilitation programs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Benefits on HRQOL | 3 months | The aim is to analyze the benefits on HRQOL of suitable correction of desaturation in COPD patients without conventional criteria for OCD but with exercise desaturation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Reduce breathlessness during exercise | 3 months | Reduce breathlessness during exercise |
| Increase exercise capacity | 3 months | Increase exercise capacity |
| Increasing physical activity | 3 months | Increasing physical activity |
Countries
Spain
Outcome results
None listed