Healthy Start: Exploring the Fuel-mediated Programming of Neonatal Growth

Conditions

Obesity, Pregnancy

Keywords

Body composition, Body size

Brief summary

The purpose of this study is to establish and follow longitudinally a cohort of ethnically diverse pregnant women and their offspring, in order to explore the hypothesis that fetal over-nutrition is associated with obesity, metabolic, and cardiovascular abnormalities in the offspring.

Brianna F. Moore, Katherine A. Sauder, Anne P. Starling, J.R Hébert, Nitin Shivappa et al. (8 authors)

UNC Libraries2024-05-07

10.17615/vj3d-p245

Body composition trajectories from birth to 5 years and hepatic fat in early childhood.

Cohen CC, Harrall KK, Gilley SP, Perng W, Sauder KA, Scherzinger A, Shankar K, Sundaram SS, Glueck DH, Dabelea D.

2022-10-017 citations

10.1093/ajcn/nqac168

Maternal Diet Quality Is Associated with Placental Proteins in the Placental Insulin/Growth Factor, Environmental Stress, Inflammation, and mTOR Signaling Pathways: The Healthy Start ECHO Cohort.

Francis EC, Dabelea D, Boyle KE, Jansson T, Perng W.

2022-03-0115 citations

10.1093/jn/nxab403

Proinflammatory Diets during Pregnancy and Neonatal Adiposity in the Healthy Start Study.

Moore BF, Sauder KA, Starling AP, Hébert JR, Shivappa N, Ringham BM, Glueck DH, Dabelea D.

2017-12-0631 citations

10.1016/j.jpeds.2017.10.030

An observational cohort study of weight- and length-derived anthropometric indicators with body composition at birth and 5 mo: the Healthy Start study.

Perng W, Ringham BM, Glueck DH, Sauder KA, Starling AP, Belfort MB, Dabelea D.

2017-06-2825 citations

10.3945/ajcn.116.149617

Associations of maternal BMI and gestational weight gain with neonatal adiposity in the Healthy Start study.

Starling AP, Brinton JT, Glueck DH, Shapiro AL, Harrod CS, Lynch AM, Siega-Riz AM, Dabelea D.

2014-12-03196 citations

10.3945/ajcn.114.094946

Interventions

OTHERMaternal factors

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Pregnant women and infants * Prior to 23 completed weeks of gestation * Live in Colorado

Exclusion criteria

* Multiple gestation * Preexisting * cancer * psychiatric disease * steroid-dependent asthma, or * diabetes * Previous premature delivery prior to 25 weeks gestation or fetal demise

Design outcomes

Primary

Measure	Time frame	Description
Fat mass	Birth	Body composition assessed via air displacement plethysmography to calculate fat mass and fat-free mass.

Secondary

Measure	Time frame	Description
Fat mass	5 months	Body composition assessed via air displacement plethysmography to calculate fat mass and fat-free mass.

Countries

United States

Contacts

Primary ContactDana Dabelea, MD, PhD

Dana.Dabelea@ucdenver.edu303-724-4414

Outcome results

None listed