Generalized Chronic Periodontitis, Osteoporosis
Conditions
Keywords
Osteoporosis, Chronic Periodontitis, Calcitonin gene Polymorphism
Brief summary
Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.
Detailed description
Periodontitis is a polymicrobial inflammatory disease which includes various modifiable and nonmodifiable risk factors. The non modifiable risk factors include genetic polymorphisms like metabolism associated genetic polymorphisms ( Vitamin D and Calcitonin). Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue with consequent increase in bone fragility and susceptibility to fractures. Bone loss is a common feature shared between periodontal disease and osteoporosis. Out of all genetic factors Calcitonin gene polymorphism contributes to the development of both osteoporosis and chronic periodontitis.
Interventions
GENETICCTR Gene
2ml blood sample collected from patients to extract DNA for Assessment of CTR Gene polymorphism
Sponsors
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and Female * Patients aged between 35.00 Year(s) to 60.00 Year(s) diagnosed with Osteoporosis and Chronic Periodontitis who are willing to participate in the study
Exclusion criteria
* Patients who are Systemically compromised and under medications such as steroids. * Patients who smoke.Pregnant and lactating mothers are excluded from the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Calcitonin gene polymorphism | 5 Months | Collection of blood samples and running the samples by PCR |
Countries
India
Outcome results
None listed