Lower Urinary Tract Symptoms
Conditions
Brief summary
Study part 1 will consist of sensory evoked cortical potential (SEP) measurements of the lower urinary tract (LUT) in healthy subjects using different stimulation frequencies from 0.25 to 3Hz to find the most effective frequency in regard to acquisition time for reliable SEP response rates. Study part 2 will consist of a series of consecutive SEP measurements in patients with LUT symptoms during low bladder volume and maximum cystometric capacity to assess reliability of measurements and influence of potential concomitant LUTS treatments.
Interventions
PROCEDUREEEG and EP measurement
Sponsors
Ulrich Mehnert
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
Yes
Inclusion criteria
healthy volunteers: * Written informed consent, * good mental and physical health, * age \>18y, Patients with LUTS and Patients with LUTS and treatment: * Written informed consent, * age \>18y, * prior urodynamic investigation, * LUTS since \>6months with or without detrusor overactivity
Exclusion criteria
healthy volunteers: * any neurological or urological pathology, * current pregnancy or lactation, * urinary tract infection, * hematuria, * any previous pelvic or spine or craniocerebral surgery, * any anatomical anomaly of the LUT or genitalia, * any metabolic disease, * any LUT malignancy, * bladder capacity \<150mL, * SDV at 60mL; Patients with LUTS and Patients with LUTS and treatment: * current pregnancy or lactation, * urinary tract infection, * gross hematuria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| N1latency of LUT SEPs | 2-3 measurements within 4-16 weeks from first exam |
Countries
Switzerland
Outcome results
None listed