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Evaluation of Conventional Antibiotic Prophylaxis During a Change of Hip or Knee Infected at a Time

Evaluation of the Effect of a Conventional Antibiotic Prophylaxis on the Positivity of Intraoperative Bacteriological Samples During a Change of Hip or Knee Infected at a Time

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02272205
Enrollment
80
Registered
2014-10-22
Start date
2014-11-01
Completion date
2017-10-31
Last updated
2025-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total Hip Replacement

Keywords

Hip replacement, Knee replacement, Knee infection, Hip infection, Antibiotic prophylaxis

Brief summary

Infection is a serious complications after undergoing total hip replacement. It occurs in about 1% of cases. The optimal treatment of these infections is discussed. The team validated by international publications change strategy of the infected prosthesis at a time. Antibiotic prophylaxis has significantly reduced the infection intraoperative contamination in orthopedic surgery rates. It must be conventionally administered before the surgical incision. In response to infection, it is typically recommended to start this antibiotic after the completion of the deep bacteriological samples, so as not to negate the risk of these samples by the prior administration of antibiotics. This attitude, however, is not formally validated by the scientific literature. In contrast, two recent publications challenge this practice, and suggest the use of a conventional antibiotic prophylaxis even in septic interventions. Our multidisciplinary team opted for a few months for this new strategy. We wish to evaluate the influence of this new approach results in the treatment of infection in total hip or knee.

Interventions

OTHERRetrospective analysis of records

Sponsors

University Hospital, Strasbourg, France
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* patients operated in service between January 2012 and July 2013 for treatment of an infection of total hip or knee.

Exclusion criteria

* patients operated in service before January 2012 and after July 2013 for treatment of an infection of total hip or knee.

Design outcomes

Primary

MeasureTime frameDescription
concordance of pre-and intraoperative bacteriological documentationpreoperative; intraoperativeconcordance of pre-and intraoperative bacteriological documentation (division into 3 classes: complete, partial, no - Chi-square test

Secondary

MeasureTime frameDescription
rates to relapse of the initial infection or a new infectionpreoperative; intraoperativerates to relapse of the initial infection or a new infection (survival curves according to Kaplan-Meier with log-rank test)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026