SCFA Metabolism
Conditions
Keywords
Butyrate, Interorgan metabolism, Short-chain fatty acids, Gut production
Brief summary
In this placebo-controlled randomized parallel study the effects of a butyrate enema on plasma short-chain fatty acids (SCFA) concentrations and fluxes from portal drained viscera, liver and the splanchnic area are investigated
Detailed description
Patients undergoing upper abdominal surgery are included. During surgery they receive a butyrate enema or placebo enema. Before and after rectal administration, plasma samples are taken from several veins and arteries to analyse SCFA concentrations and fluxes from portal drained viscera, liver and the splanchnic area.
Interventions
DIETARY_SUPPLEMENTSodium butyrate
Patients recieved an enema containing butyrate or a placebo during upper abdominal surgery.
DIETARY_SUPPLEMENTNaCl
Sponsors
Top Institute Food and Nutrition
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients undergoing open liver resection or pancreaticoduodenectomy
Exclusion criteria
* known parenchymal liver disease * presence of ileostomy or colostomy * patients with inflammatory bowel disease * antibiotics, prebiotics or probiotics 2 months prior to surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma SCFAs | 0, 5, 15, 30 min after administration |
Countries
Netherlands
Outcome results
None listed