Other Allergic Rhinitis
Conditions
Keywords
1 prevalence, 2 children, 3 local allergic rhinitis
Brief summary
* To determine prevalence of local allergic rhinitis (LAR) * To evaluate clinical characteristic and severity of local allergic rhinitis * To measure changing of tryptase and Specific IgE for Dermatophagoides pteronyssinus (Dp) after nasal allergen provocation test (NAPT)
Detailed description
Children 8-18 years with NAR were recruited. A NAPT with Der p 1 solutions (NAPT-DP) at 200 AU/mL, 600 AU/mL and 2000 AU/mL at 15-minute interval was performed, respectively. The immediate responses to NAPT-DP were assessed using symptoms score, peak nasal inspiratory flow (PNIF) and acoustic rhinometry (ARM). The nasal tryptase and sIgE-DP were measured at baseline, 15 min and 1 h after positive NAPT-DP. Allergic rhinitis (AR) patients were used as positive control.
Interventions
PROCEDUREnasal allergen provocation test
nasal allergen provocation test
Sponsors
Mahidol University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
8 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Children 8-15 years who were diagnosed with nonallergic rhinitis (NAR) at least 1 year * No respiratory infections in the previous 4 weeks * No following treatment of * systemic corticosteroid 4 weeks * intranasal corticosteroid 2 weeks * oral antihistamine 1 week * leukotriene antagonist 1 week
Exclusion criteria
* Patients with underlying disease: * chronic rhinosinusitis and nasal polyp * immunological disease * chronic renal disease * hepatobiliary disease * cardiovascular disease * cancer * Parental withdraw consent * Patient with uncontrolled asthma, peak expiratory flow rate (PEFR) \< 80% of predicted
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| prevalence of local allergic rhinitis (LAR) | 1 year | positive nasal allergen provocation test with Der p1 |
Countries
Thailand
Outcome results
None listed