Irritable Bowel Syndrome
Conditions
Keywords
Irritable bowel syndrome, Gut microbiota, Soluble dietary fiber
Brief summary
The purpose of this study is to investigate the effect of pectin, a kind of soluble dietary fiber, on clinical symptoms, gut microbiota and the immune status in patients with diarrhea-predominant irritable bowel syndrome
Detailed description
Patients were randomized to receive either pectin or placebo. Treatment consisted of 6 weeks supplementation with pectin (fiber group) or placebo (maltodextrin). We evaluated the clinical symptoms, gut microbiota and the immune markers in two groups.
Interventions
DIETARY_SUPPLEMENTPectin
Pectin （Andeli Ltd. Yantai, China）, 24g/d for six weeks
DIETARY_SUPPLEMENTmaltodextrin
Sponsors
Nanjing PLA General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* All patients(age≧18y) * Admitted for diarrhea-predominant irritable bowel syndrome
Exclusion criteria
* Mental disorders * Cancer * Inflammatory bowel disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| efficacy: change of stool frequency, faecal form and clinical symptoms score | six weeks after inclusion | change from baseline in stool frequency, faecal form (Bristol stool scale) and clinical symptoms score (7-point Likert scale) at six weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| efficacy: gut microbiota | six weeks after inclusion | real-time PCR |
| efficacy: cytokine ratios | six weeks after inclusion | Cytokine production |
Outcome results
None listed