Atrial Fibrillation
Conditions
Keywords
atrial fibrillation, atrial electrophysiology, stroke, vascular stiffness
Brief summary
Paroxysmal atrial fibrillation can only be diagnosed during episodes when the arrhythmia is present. The investigators hypothesize that the activation of the atrial myocardium resulting in the p-wave of the ecg should display abnormalities in diseased atria which are vulnerable for AF.
Detailed description
In the first part of this trial different diagnostic techniques to detect arrythmogenic substrates of atrial fibrillation will be tested. If suitable parameters can be identified, a follow up trial to identify patients at risk for AF will be conducted before a stroke happens. Parameters tested are 1. Electrophysiological differences between patients with paroxysmal AF and no history of AF 2. Vascular Stiffness detected by an iPhone app All patients will undergo a cardiogoniometrie and a pulse wave analysis with an iPhone. Each exam takes 5 minutes.
Interventions
DEVICEECG
Patients receive a 5 Minute ECG recording and have their pulse recorded by an iPhone.
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* paroxysmal atrial fibrillation in sinus rhythm at presentation
Exclusion criteria
* acute cerebral trauma * antiarrhythmic medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Beat to beat variation of the electrical activation vector of the atrium | Once during the exam (baseline) - No further follow up planned | Test if the beat to beat Variation of the electrical activation of the atrium differentiates between the group of patients with paroxysmal AF and no AF in history. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Averaged slope of pressure-curve | Once during exam (5min, baseline) - No further follow up planned | Test if the steepness of the slope of the pressure curve recorded with the iPhone differs between the two Groups. |
| Heart rate variability | Once during exam (5min, baseline) - No further follow up planned | Test if heart rate variability recorded with the iPhone differs between the two Groups. |
Countries
Switzerland
Outcome results
None listed