Metabolic Cardiovascular Syndrome
Conditions
Keywords
Metabolic syndrome, Diabetes, Muscle strength, Aerobic exercise, Bicycle, Brain-derived neurotrophic factor
Brief summary
The subjects with MetS or type 2 diabetes were enrolled for this exercise-training program. All participators underwent an indoor bicycle exercise for twelve weeks. In addition to demographic data and biochemical tests were determined after an overnight fasting. Extension of muscle strength was detected in the dominant lower extremity.
Detailed description
This prospective open-labeled study was conducted in Taichung Veterans General Hospital. The adult participants with metabolic syndrome and/or type 2 diabetes were enrolled. MetS. The procedures were fully explained to all subjects before the cardiopulmonary exercise test. ll enrolled subjects received a scheduled twelve-week program for exercise-training program. A commercially available bicycle with an indoor bicycle trainer are used as the home exercise training modality. All medications were not allowed to be changed during the study.
Interventions
BEHAVIORALbicycle exercise
All enrolled subjects received a scheduled twelve-week exercise program. A commercially available bicycle (Giant CS800, Taichung, Taiwan) with an indoor bicycle stand (Giant Cyclotron Mag, Taichung, Taiwan) was used as the home exercise training modality.
Sponsors
Taichung Veterans General Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Adult with metabolic syndrome or type 2 diabetes
Exclusion criteria
* hyperglycemic crisis or HbA1c \> 12%; * serum creatinine levels greater than 200 mmol/L; * acute or chronic infectious diseases; * limitations in the ability to undertake regular exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic syndrome | 12 weeks | Components of metabolic syndrome based on the modified Third Report of the National Cholesterol Education Program (NCEP) criteria |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Muscle strength | 12 weeks | A Biodex Isokinetic Dynamometer (Biodex Medical Systems, Inc., Shirley, New York, USA) was used to evaluate the muscle strength of the subjects |
| Brain-derived neurotrophic factor | 12 weeks | Serum concentration of Brain-derived neurotrophic factor (enzyme immunoassay method, R&D Systems, Minneapolis, U.S.A.) |
| Arterial stiffness | 12 weeks | Pulse wave velocity |
Outcome results
None listed