Effect of the Addition of Ketamine to Sevoflurane Anesthesia in Electroconvulsive Therapy

Turgut Ozal Medical Center Department of Anesthesiology and Reanimation

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02267980

Enrollment

Registered

2014-10-20

Start date

2014-07-31

Completion date

2014-10-31

Last updated

2014-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depressive Disorder

Keywords

Electroconvulsive therapy; sevoflurane; ketamine

Brief summary

The investigators evaluate the effects of a subanesthetic dose of ketamine, administered as an adjunct to sevoflurane, on duration of seizure activity, hemodynamic profile and recovery times during electroconvulsive therapy (ECT) in patients with major depression.

Detailed description

Patients will randomly allocate, to either a sevoflurane-ketamine (Group SK), sevoflurane-saline (Group SS) receiving group. Mean arterial pressure (MAP) and heart rate (HR) will record prior to anesthetic induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 min after the seizure has ended (T3, T4, T5, and T6, respectively). Motor and EEG seizure durations will be recorded.

Interventions

DRUGSevoflurane

Inhalation anesthetic agent

DRUGKetamine

Intravenous anesthetic agent

DRUGSaline

Isotonic solution for placebo group

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Major depressive patients

Exclusion criteria

* Pregnancy * Have a history of myocardial infarction in the previous six months * Atrial fibrillation or flutter * Heart block * Unregulated hypertension * Cerebrovascular diseases * A known drug allergy

Design outcomes

Primary

Measure	Time frame	Description
seizure duration	During electroconvulsive therapy (30 minutes)	the time from application of the ECT stimulus to the cessation of tonic-clonic motor activity in the isolated arm.

Secondary

Measure	Time frame	Description
Mean arterial pressure (MAP)	During Electroconvulsive therapy (30 minutes)	Mean arterial pressure (MAP) will be recorded prior to anesthetic induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 min after the seizure has ended (T3, T4, T5, and T6, respectively).
Heart rate (HR)	During Electroconvulsive therapy (30 minutes)	Heart rate (HR) will be recorded prior to anesthetic induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 min after the seizure has ended (T3, T4, T5, and T6, respectively).

Countries

Turkey (Türkiye)

Contacts

Primary ContactFeray Erdil, MD

feray.erdil@inonu.edu.tr904223410660

Backup ContactMahmut Durmus, MD

mahmut.durmus@inonu.edu.tr904223410660

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026