Cirrhosis
Conditions
Brief summary
Individuals with Cirrhosis have been shown to have a low aerobic capacity. While supervised exercise training has been shown to be an effective intervention to remedy this, there is currently no data on home based exercise interventions in this population. This study will evaluate the effects of a home based exercise program on the aerobic capacity of enrolled early stage liver cirrhosis patients, as well as changes in quality of life, thigh muscle thickness, and thigh muscle oxygen consumption.
Interventions
BEHAVIORALHome based Aerobic exercise training
Sponsors
University of Alberta
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
\- Age \>18 and less than or equal to 70 years Liver Cirrhosis Child Pugh Class A or B If required, primary or secondary Variceal prophylaxis in place
Exclusion criteria
\- Post-liver transplantation Hepatocellular carcinoma beyond transplant criteria Active non-hepatocellular carcinoma malignancy Significant cardiac disease Hemoglobin (\<80 g/L) Oxygen saturation at rest \<95% Known myopathy Chronic renal failure on dialysis Physical impairment making it impossible to ride an exercise bike or treadmill Orthopedic abnormality preventing exercise training HIV infection Patient unwilling to consent to study Child Pugh class C
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in peak exercise pulmonary oxygen uptake (VO2peak). | Baseline (day 1) and Study End (8 weeks) |
Secondary
| Measure | Time frame |
|---|---|
| Change in muscle mass as measured by thigh ultrasound | Baseline (day 1) and Study end (8 weeks) |
| Change in quality of life - Chronic Liver Disease Questionnaire | Baseline (Day 1) and Study completion (8 weeks) |
| Change in muscle oxygen extraction and consumption as measured by MRI | Baseline (day 1) and study completion (8 weeks) |
Countries
Canada
Outcome results
None listed