Early Goal Directed Therapy in Sepsis by Emergency Medical Services

Early Goal Directed Therapy in Sepsis by EMS

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02266654

Enrollment

Registered

2014-10-17

Start date

2014-10-31

Completion date

2017-05-31

Last updated

2017-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Keywords

Emergency Medical Services, Lactic Acid, Sepsis

Brief summary

The goal is to evaluate the best way for paramedics and hospitals to work together to treat septic patients as quickly as possible. The investigators think that the best thing to do for septic patients is to identify and treat them as early as possible. This research will test this. The investigators think that if paramedics identify septic patients and begin treatment with fluids in the ambulance, then the patient will do better in the long run. The paramedic will also tell the hospital that a septic patient will be there soon. The caregivers can prepare and be ready to provide care as soon as the patient arrives. With this research, the investigators would like to see if these steps help patient outcomes.

Interventions

OTHERIV fluids

Normal Saline 0.9%

OTHERHospital Notification

Prehospital providers will notify the receiving hospital over the radio or telephone that they are transporting a patient who meets Sepsis Criteria

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

17 Years to No maximum

Healthy volunteers

Inclusion criteria

* Older than 17 years of age * Suspected to having an infection * Meets 2 of 3 systemic inflammatory response criteria: heart rate \> 90 beats per minute, respiratory rate \>20 breaths per minute, temperature \>38°C or \<36°C

Exclusion criteria

* Transfer from another hospital * Patients, coming from a rehabilitation/nursing facility where antibiotics were given prior to transfer * Pregnant patients * Prisoners.

Design outcomes

Primary

Measure	Time frame
Time to antibiotics	During the Emergency Department stay (expected to be 5 hours)

Secondary

Measure	Time frame
Mortality	Participants will be followed for the duration of hospital stay, an expected average of 1 week
Need for pressors in the Emergency Department	During the Emergency Department stay (expected to be 5 hours)
Admitted to the Intensive Care Unit from the Emergency Department	During the Emergency Department stay (expected to be 5 hours)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026