Sepsis, Septic Shock
Conditions
Keywords
coagulopathy, hydrocortisone, organ failure, hemodynamic improvement induced by hydrocortisone
Brief summary
The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock. And discuss the probable mechanism by which little doses of hydrocortisone influence coagulation system in sepsis.
Detailed description
Patients were randomized to receive either low-dose hydrocortisone or matching placebo.Severity of coagulopathy was estimated using ISTH DIC score. We determined the complications and mortality in two groups, and analyzed the relationship between hydrocortisone and coagulopathy.
Interventions
DRUGHydrocortisone
Hydrocortisone hemisuccinate (Roussel-Uclaf, Romainville, France), 50 mg intravenously every 6 hrs
Sponsors
Nanjing PLA General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* All patients(age≧18y) * Admitted for septic shock were considered eligible if they had no life-threatening systemic disease (ASA groups 1\ 3)
Exclusion criteria
* Lactation * Mental disorders * Disseminated cancer * Secondary cancers * Inflammatory bowel disease, or diseases hindering epidural analgesia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| coagulopathy | 30 days after inclusion | ISTH score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| death | 30 days after inclusion | — |
| clinical complications | 30 days after inclusion | MODS SOFA score |
Outcome results
None listed