Cirrhosis Related Parkinsonism
Conditions
Brief summary
After successful screening of liver cirrhosis patients attending ILBS OPD for signs of parkinsonism ( tremor, rigidity or bradykinesia, any 2 of 3). Diagnosis of hepatic/cirrhosis related parkinsonism will be made. Patients will be randomized into Bromocriptine and Placebo. Patients will be followed up every month in OPD (Out Patient Department), ILBS (Institute of liver & Biliary Sciences) for 3 months. Detailed neurological examination will be done at each visit & UPDRS (Unified Parkinson's Disease Rating Scale ) score will be calculated.
Interventions
DRUGLactulose+Rifaximin +Bromocriptine
Sponsors
Institute of Liver and Biliary Sciences, India
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with cirrhosis of liver with signs of parkinsonisms * Patients consented for the study protocol by signing the informed consent.
Exclusion criteria
* Age \< 18 years. * Patient s with HCC (Hepatocellular Carcinoma). * Patients diagnosed as Wilsons disease. * Patient who withdrew or non complaint to the study protocol. * ALF (Acute Liver failure) * Classical Parkinsonism * Atypical Parkinsonism * Pregnancy * Hypotension * Uncontrolled hypertension * CAD * Psychiatric illness * Acute episode of Hepatic encephlopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be decrement in UPDRS (Unified Parkinson's Disease Rating Scale) score by 30 %. | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| The secondary end point will be decrement in UPDRS (Unified Parkinson's Disease Rating Scale) score of 10% to 30%. | 3 months |
Countries
India
Outcome results
None listed