Obesity, Obstructive Sleep Apnea, Sleep
Conditions
Keywords
Obesity, Obstructive Sleep Apnea, Sleep Habits, Bariatric Surgery, Cohort
Brief summary
The main objective of the study is to identify the determinant of sleep characteristics of obese patients attempting a tertiary clinical center for obesity management, including bariatric surgery. More accurately the questions addressed are: * What are the determinants of the sleep habits (sleep duration, chronotype) and of their evolution * What are the determinants of sleep breathing disorders (sleep apnea, obesity hypoventilation syndrome) and of their evolution
Detailed description
Adult obese patients, attempting a tertiary medical center for the management of their obesity, are asked to participate in a cohort study. Data issued from routine clinical practice are collected. Medical history and actual medical condition: * Type 2 or type 1 diabetes * Dyslipidemia * Hypertension * Cardiovascular diseases * Steatohepatitis/cirrhosis * Gastric disorders * Nutritional deficiency * Obstructive sleep apnea/Obesity hypoventilation syndrome All patients who do not have a previously known sleep apnea syndrome are evaluated by nocturnal polygraphy. Lifestyle and sleep habits, as well as social and economic characteristics, are assessed by questionnaires. Patients are asked to provide blood sample to constituate a serum bank and gene bank. Patients are asked, if undergoing bariatric surgery, to provide subcutaneous and visceral fat. When patients benefit from bariatric surgery, follow-up data are collected at 3 months, 6 months, 12 months after bariatric surgery and yearly after that for at least 5 years.
Interventions
None listed
Sponsors
Act For Chronic Diseases
HP2 laboratory INSERM U1042
University Grenoble Alps
University Hospital, Grenoble
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Class II or class III obesity (BMI ≥ 35 kg/m²). Only patients undergoing surgery to realize a second surgical line of management of their obesity may have a lower BMI, if the surgical recovery is motivated by a technical defect of the first assembly.
Exclusion criteria
* Refusal to participate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sleep breathing disorders | 5 years | Evolution of sleep breathing disorders during obesity management, especially after bariatric surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sleep habits | 5 years | Evolution of sleep habits during obesity care, especially after bariatric surgery |
Other
| Measure | Time frame | Description |
|---|---|---|
| Metabolic diseases | 5 years | Evolution of metabolic diseases during obesity care, especially after bariatric surgery |
| Other respiratory diseases | 5 years | Evolution of other respiratory diseases during obesity care, especially after bariatric surgery |
| Complications of bariatric surgery | 5 years | Recording of complications after bariatric surgery |
Countries
France
Contacts
Primary ContactAnne-Laure Borel, Pr MD PhD
Backup ContactMatthieu Lesgoirres
Outcome results
None listed