Huntington's Disease
Conditions
Brief summary
Deep Brain Stimulation (DBS) of the Globus pallidus internus(GPi) is useful in the treatment of different forms of chorea, including Huntington's disease (HD).
Interventions
DEVICEDeep Brain Stimulation
Sponsors
Beijing Tiantan Hospital
Beijing Pins Medical Co., Ltd
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Subject clinically symptomatic and genetically confirmed Huntington Disease (number of CAG repeats\>= 36) 2. Moderate stage of the disease (UHDRS motor\>= 30) 3. Predominant movement disorder 4. Compliance of the patient, stable cognition during a 6 months phase prior to inclusion (Mattis Dementia Rating Scales（MDS）\>/= 120) 5. Signed informed consent.
Exclusion criteria
1. Patients with hearing impairment; 2. Failures of important organs and in severe conditions; 3. Be reluctant or disabled to receive neuropsychological assessments; 4. Participate in other clinical trial; 5. Has a life expectancy of \< 1 year. 6. The investigator and/or enrollment review committee, would preclude participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Huntington's Disease Rating Scale(UHDRS) | 12 month |
Contacts
Primary ContactJia Fumin, PhD
Outcome results
None listed