Hookworm Immune Regulation Project

Study of Immuno-regulatory Mechanisms Induced by Hookworm Infection

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02262403

Acronym

HIRP-01

Enrollment

Registered

2014-10-13

Start date

2014-08-01

Completion date

2021-12-31

Last updated

2021-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hookworm Infection

Keywords

Hookworm, Helminths, Treg, Immune regulation, Vietnam, Allergic diseases

Brief summary

The main objective of this study is to characterize the regulatory immune response induced by hookworm in an infected Vietnamese rural population from the periphery of HCM, evolution after infection treatment and during potential naturally reinfection.

Detailed description

Population: 20 healthy adults (18-65 years) infected and non infected by Hookworm will be recruited and treated according to Good Clinical Practice recommendations. Allergy will be excluded by skin prick tests. Amount and phenotype of Treg will be explored at several time points. Subsequent culture with environmental antigen will be performed on cryopreserved cells.

Interventions

OTHERBlood and feces sampling

Blood and feces samples will be examined after 14 days, 28 days, 3 months and 16 months. This will require blood and feces sampling. The study is therefore defined as 'interventional' rather than 'observational' as it includes acts outside the standard of care.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* 18-65 years old adults in good health status * To live in rural regions at risk of soil transmitted helminthes * Hookworm infection (infected group) * Uninfected by Hookworms (control group)

Exclusion criteria

* Pregnant woman * Positive allergic history * Auto-immune and/or HIV disease * Antihelminthics drug in the last 6 months and other current parasitic infection

Design outcomes

Primary

Measure	Time frame	Description
Amount and phenotype of Treg	0-12 weeks	Four colors flow cytometry Treg measurements and phenotyping (FACSCantoII).

Other

Measure	Time frame	Description
PBMC culture and cryopreservation	after 12 weeks	Assessment of the orientation of the adaptative immune response to Dermatophagoides pteronyssinus.Subsequent Treg function testing and cell cultures (with environmental antigen) on cryopreserved PBMC (Peripheral Blood Mononuclear cells).

Countries

Vietnam

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026