Myelodysplastic Syndrome
Conditions
Brief summary
Patients with myelodysplastic syndrome (MDS) have an ineffective hemopoiesis and often suffer from anemia. This can lead to red blood cell transfusion dependency and iron overload. Iron overload can affect the liver and lead to liver fibrosis and worst case cirrhosis. Ferritin is usually used to monitor the iron overload. In this study MDS patients will have a transient elastography performed which measures the liver's stiffness. The purpose is to investigate whether liver stiffness measurements are coherent to ferritin levels.
Detailed description
Transient elastography is noninvasive and has no side effects. No liver biopsy will be performed due to serious side-effects and risks in this patientgroup. The results of the transient elastography will be compared to the patient's ferritin levels and the numbers of months the patients have had MDS to find out if there is a correlation. Furthermore we will compare the liver stiffness measurements in the patients with higher ferritin levels to those who have lower ferritin levels. We will also compare the liver stiffness measurements in patients who are red blood cell transfusion dependent compared to those who are red blood cell transfusion independent. We will also compare liver stiffness measurements in the patients with a high alanine aminotransferase (ALAT) compared to those with normal ALAT.
Interventions
All patients will have a transient elastography performed as a measure of liver stiffness.
Sponsors
Zealand University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with a bone marrow describing myelodysplasia Among these: * Patients with myelodysplastic syndrome (MDS) * Patients with acute myeloid leukemia (AML) transformed from MDS * Patients with chronic myelomonocytic leukemia (CMML) with dysplasia * Patients with myelodysplastic/myeloproliferative neoplasm, unclassifiable
Exclusion criteria
Body mass index (BMI) of 30 or higher than 30 \- History with other known liver diseases Among these: * Patients with chronic viral hepatitis C infection * Patients with chronic viral hepatitis B infection * Patients with alcoholic liver cirrhosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Liver stiffness | Transient elastography (Fibroscan) 5 minutes | Liver stiffness is measured in kilopascal (kPa) |
| Iron overload: Ferritin | Blood samples 5 minutes | Ferritin is measured in micrograms per liter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Disease period | Information regarding time of diagnosis will be obtained retrospectively | Period of disease will be calculated in months |
| Red blood cell transfusion dependency | Information regarding transfusion will be obtained retrospectively | Transfusion dependency will be defined as having at least one red blood cell transfusion every other eight weeks over a period of four months prior to the date of the fibroscan. Red blood cell dependency will be either yes or no |
| Liver inflammation: Alanine aminotransferase | Blood samples 5 minutes | Alanine aminotransferase is measured in units per liter |
Countries
Denmark
Outcome results
None listed