New Prognostic Kidney Function Markers in Emergency Patients New Markers of Kidney Function in ED Patients

New Prognostic Kidney Function Markers in Emergency Patients

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02261909

Enrollment

Registered

2014-10-10

Start date

2015-05-31

Completion date

2016-06-30

Last updated

2022-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Contrast Media

Keywords

Emergency Medicine, diagnosis

Brief summary

NephroCheck is measuring the concentration of a certain protein combination in the urine of patients. In elevated values there is a probability of renal failure (already proven in intensive care patients). The investigators would like to investigate whether the investigators can predict renal failure in patients receiving contrast enhanced CT's in the emergency department. That would lead to an earlier nephrologist consult in those patients.

Detailed description

The use of contrast agents can - especially in already in impaired renal function - lead to a decline in real function. The contrast enhanced CT is especially in emergency patients an important diagnostic tool for example in the detection of pulmonary embolism or mesenteric ischemia. Creatinine has been used as a marker for real function so far. But the investigators all know that creatinine is not a perfect marker especially as it is influenced by age, sex, weight and muscle mass. Especially in the diagnosis of acute renal failure creatinine does not allow and recent change in the kidney function. This prospective, unicentric study should therefore investigate two new markers in emergency patients who need an emergency contrast enhanced CT to early predict pending kidney function decline.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients in the emergency department who have the indication for contrast enhanced CT and a predicted hospital admission time of 48 hours or longer.

Exclusion criteria

* children, pregnant women * dialysis * patients with kidney transplants * patients on steroids or further immunocompromised

Design outcomes

Primary

Measure	Time frame	Description
Renal function	participants will be followed for the duration of hospital stay, an expected average of 7 days	renal function at discharge from hospital (creatinine and BUN measured at day of discharge)

Secondary

Measure	Time frame	Description
Requirement for dialysis	participants will be followed for the duration of hospital stay, an expected average of 7 days	dialysis required throughout hospital stay
Admission to ICU	participants will be followed for the duration of hospital stay, an expected average of 7 days	admission to ICU required throughout hospital stay

Countries

Germany

Outcome results