Bronchitis, Chronic, Lung Diseases, Obstructive, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Respiratory Tract Diseases
Conditions
Brief summary
To determine the feasibility of delivering different community nutritional interventions to chronic obstructive pulmonary disease (COPD) patients at moderate or severe risk of malnutrition following a hospitalisation for an acute exacerbation of COPD.
Interventions
DIETARY_SUPPLEMENTFood fortification
DIETARY_SUPPLEMENTOral Nutritional Supplements
Sponsors
Medical Research Council
The Hillingdon Hospitals NHS Foundation Trust
Royal Brompton & Harefield NHS Foundation Trust
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Ability to consent * Patients at moderate or severe risk of malnutrition * Adults over the age of 40 * Hospitalised with an AECOPD
Exclusion criteria
* Receiving long term parental or enteral nutrition * Inability to swallow or difficulty liquids * Lactose intolerance, galactosaemia, cow's milk protein allergy or intolerance * Co-existing active cancer, progressive neurological condition or active GI disorder. * Receiving palliative care with expectation of death within 3 months * Cognitive dysfunction or unable to consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in four-metre gait speed (m/s) following nutritional support | Change from baseline to 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Change in weight (kg) following nutritional support | Change from baseline to 12 weeks |
| Change in fat free mass (kg) as measured by bioelectrical impedence following nutritional support | Change from baseline to 12 weeks |
| Change in fat free mass index (kg/m2) as measured by bioelectrical impedence following nutritional support | Change from baseline to 12 weeks |
Countries
United Kingdom
Outcome results
None listed