Complications of Organ Transplant, Infection in Solid Organ Transplant Recipients, Respiratory Viral Infection
Conditions
Brief summary
A retrospective cohort of solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients will be assembled to determine the incidence of respiratory viral infections diagnosed during an inpatient admission in the first year post-transplant. A sub-cohort of patients that develop a respiratory viral infection within one year of transplantation will be leveraged to investigate factors associated with mortality in the three months after respiratory viral infection.
Detailed description
The purpose of the study is to 1) Determine the incidence of respiratory viral infections diagnosed during the first year post SOT and HSCT; 2a) Determine the all-cause mortality within 3 months of a respiratory viral infection diagnosed during an inpatient admission in the first year post SOT and HSCT; 2b) Determine the proportion of deaths within 3 months of a respiratory viral infection diagnosed during an inpatient admission deemed to be directly attributable to that infection; and 3) To identify factors known at time of onset of the inpatient respiratory viral infection that are associated with all-cause mortality. The study cohort will consist of any SOT or HSCT recipient ≤18 years of age that received their transplant between January 1st, 2010 and June 30th, 2013. Th cohort will determine the incidence of respiratory viral infections diagnosed during an inpatient admission in the first year post-transplant. A sub-cohort of patients that develop a respiratory viral infection within one year of transplantation will be leveraged to investigate factors associated with mortality in the 3 months after respiratory viral infection. Baseline and demographic characteristics will be summarized by standard descriptive summaries. Categorical variables will be summarized by frequencies while continuous variables will be summarized using mean, standard deviation and/or median, twenty-fifth and seventy-fifth percentiles, minimum, and maximum. This is a minimal risk study using data that will be collected retrospectively from medical charts. The only potential risk would be loss of confidentiality.
Interventions
None listed
Sponsors
University of Washington
Children's Hospital of Philadelphia
Albert Einstein College of Medicine
Baylor College of Medicine
St. Jude Children's Research Hospital
University of Cincinnati
University of Pittsburgh
Duke University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* Males or females age 0 to \<18 years at the time of HSCT or SOT * Transplantation occurred between January 1st, 2010 and June 30th, 2013.
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of respiratory viral infection | 1 year post transplant | Pediatric SOT/HSCT recipients who do not develop respiratory viral infection within 1 year following transplant |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality of respiratory viral infection | 3 months after respiratory viral infection | Determine the all-cause mortality within 3 months of a respiratory viral infection diagnosed during an inpatient admission in the first year post SOT and HSCT. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Factors associated with all-cause mortality of respiratory viral infection | 3 months after respiratory viral infection | This tertiary aim will include just those patients that had an inpatient respiratory viral infection. The analysis will explore the association of factors known at time of onset of the respiratory viral infection with 3 month all-cause mortality |
Countries
United States
Outcome results
None listed