Carotid Stenosis, Coronary Stenosis
Conditions
Brief summary
The purpose of this study is to evaluate the potential benefit of systematic preoperative coronary angiography followed by selective coronary artery revascularization on the incidence of myocardial infarction (MI) in patients without a history of coronary artery disease (CAD) and undergoing carotid endarterectomy (CEA).
Detailed description
Patients candidates for CEA, with no history of CAD, a normal electrocardiogram (ECG), and a normal cardiac ultrasound were randomized in two groups. In group A (n = 216) all patients underwent coronary angiography before CEA +- coronary artery revascularization. In group B (n = 210) CEA was performed without coronary angiography.
Interventions
OTHERPreoperative coronary angiography
If coronary disease is detected percutaneous intervention (PCI) or coronary artery bypass grafting (CABG) is applied
OTHERStandard cardiac workup
EKG, transthoracic cardiac echocardiogram
Sponsors
University of Roma La Sapienza
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* indication for carotid endarterectomy * no clinical sign or history of ischemic heart disease * no electrical signs of cardiac ischemia * left ventricular ejection fraction \>50% at transthoracic echocardiogram.
Exclusion criteria
* disabling stroke (mRS ≥3) * non atherosclerotic carotid disease * severe intracranial carotid artery stenosis * contra-indications to heparin, aspirin or clopidogrel.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Non-fatal and fatal myocardial infarction | 30 days through year 3 |
Secondary
| Measure | Time frame |
|---|---|
| All-cause and cardiovascular mortality | 30 days through year 3 |
Outcome results
None listed