Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion

Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02260206

Enrollment

Registered

2014-10-09

Start date

2014-07-31

Completion date

2023-10-31

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pericardial Effusion

Keywords

Pericardial Effusion, Colchicine, arrhythmia Recurrence, pericardiocentesis

Brief summary

The effects colchicine administration for acute pericardial effusion after radiofrequency catheter ablation (RFCA) of atrial fibrillation on the recurrences of arrhythmia.

Detailed description

RFCA was started as a rhythm control of atrial fibrillation about 10 years before and the superiority of RFCA to medical treatment has been continuously reporting, so RFCA is globally performed nowadays. Acute pericardial effusion could occur during RFCA as complication, that might be developed to cardiac tamponade needed immediate pericardiocentesis. The inflammation developed after pericardiocentesis might be associated with the recurrences of atrial fibrillation, it could be presumed by the frequent occurrence of atrial fibrillation after open-heart surgery. The inflammation can be suppressed by administration of colchicine and the effects of colchicine have been proven to decrease the development of atrial fibrillation.

Interventions

DRUGColchicine

Impact of Colchicine therapy on arrhythmia Recurrence after Acute Pericardial Effusion following Catheter Ablation of Atrial Fibrillation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Intervention model description

None (Open label)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients needed to pericardiocentesis during RFCA for paroxysmal or persistent atrial fibrillation.

Exclusion criteria

* Hypersensitivity on Colchicine * The existence of intra-cardiac thrombus on trans-esophageal echocardiography * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
recurrence of atrial arrhythimia	1 year after colchicines administration	Assessment of the recurrence of atrial arrhythimia 1 year after colchicines administration

Secondary

Measure	Time frame	Description
recurrence of atrial arrhythimia	3 year after colchicines administration	Assessment of the recurrence of atrial arrhythimia 3 year after colchicines administration

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026