Energy Balance, Blood Glucose
Conditions
Brief summary
The ability to control our blood glucose (sugar) concentrations after a meal is a strong predictor of the risk of disease. Our bodies respond to glucose ingestion by reducing the amount of glucose from the liver entering the bloodstream. At the same time muscle increases the amount of glucose it take up from the bloodstream. This ensures that our blood glucose levels do not get too high. The investigators want to understand what happens to these processes following exercise after breakfast and after an overnight fast. In addition, the investigators also want to understand whether exercising with or without breakfast influences our appetite, food intake and activity levels later in the day.
Interventions
BEHAVIORALExercise
Moderate intensity exercise
DIETARY_SUPPLEMENTBreakfast
Breakfast consumption
Sponsors
University of Stirling
University of Birmingham
University of Bath
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
* Males. * Aged 18-49. * Individuals free from known cardiovascular, metabolic or joint disease as determined by standard health questionnaire. * Habitual regularly participating in exercise (minimum of 3 sessions per week on average) * Non-smoker
Exclusion criteria
* Known or suspected food intolerances, allergies or hypersensitivity. * Any bleeding disorder or taking medication which impacts blood coagulation. * Known tendency towards keloid scarring. * Known sensitivity or allergy to any local anaesthetic medicines. * Any reported use of substances which may pose undue personal risk to participants or introduce bias into the experiment. * Any other condition or behaviour deemed either to pose undue personal risk to participants or introduce bias into the experiment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exogenous glucose appearance rate | 120 minutes | Exogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes). |
| Energy balance | 24 hours | Energy balance (intake minus expenditure) over 24 h from the beginning of the trial |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Energy intake | 24 h | Weighted energy intake over 24 hours from the beginning of the trial. |
| Endogenous glucose appearance rates | 120 minutes | Endogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes). |
| Exogenous glucose appearance rates | 120 minutes | Exogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes). |
| Energy expenditure | 24 h | Energy expenditure, derived from indirect calorimetry, acccelerometry and heart rate monitoring. |
| Glucose clearance rates | 120 minutes | Glucose clearance rates following an oral glucose tolerance test (total clearance over 120 minutes). |
Countries
United Kingdom
Outcome results
None listed