Diabetes Mellitus, Type 2
Conditions
Keywords
Glycemic control, Exercise
Brief summary
A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The reason IW is superior is unknown. This study will look into whether it is the larger peak intensity during IW or if it is the alternating exercise pattern that is responsible for the larger improvements seen. Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions: 1. One hour of rest (Con) 2. One hour of classical interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW3) 3. One hour of fast alternating interval walking (repeated cycles of 1 min of fast and 1 min of slow walking; IW1). After the interventions subjects will undergo a standardized mixed meal tolerance test, with consecutive measurements of blood glucose, insulin and c-peptide.
Interventions
BEHAVIORALControl
One hour of rest.
BEHAVIORALIW3
A one hour exercise bout with repeated cycles of 3 min of fast and 3 min of slow walking
BEHAVIORALIW1
A one hour exercise bout with repeated cycles of 1 min of fast and 1 min of slow walking
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Type 2 diabetes mellitus * Body mass index \> 18 but \< 40 m2/kg * Agreement to pause antidiabetic medication from 2 days before to after each trial
Exclusion criteria
* Pregnancy * Smoking * Use of exogenous insulin * Contraindication to increased levels of physical activity * Evidence of thyroid, liver, lung, heart or kidney disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glycemic control | Within the first 4 hours after the interventions | Glycemic control will be measured after each intervention. Subjects will receive a standardized mixed meal tolerance test (MMTT), and blood glucose values will be obtained during the test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin secretion | Within the first 4 hours after the interventions | Insulin and C-peptide will be measured during the MMTT |
| Insulin sensitivity | Within the first 4 hours after the interventions | From the measurements og glucose and insulin during the MMTT, various indices of insulin sensitivity will be assessed |
Countries
Denmark
Outcome results
None listed