Iron Deficiency
Conditions
Brief summary
Investigation of Iron Bioavailability from extruded rice grains fortified with Ferric Pyrophosphate alone or in combination with different Zinc Compounds; Ferrous Sulfate serves as a Reference.
Detailed description
Ferric Pyrophosphate (FePP) is a water-insoluble, food grade, iron compound widely used to fortify rice and other foods as it causes no organoleptic changes to the food vehicles. However, it is only of low absorption in man and its absorption can be influenced by a variety of compounds. The effect of co-fortification of rice with ZnO respectively ZnSO4 on iron bioavailability in extruded rice fortified with FePP has never been investigated.
Interventions
Rice fortified with Ferric Pyrophosphate and Zinc Oxide (ZnO)
OTHERFerrous sulfate
Rice fortified with Ferrous Sulfate (ZnSO4)
OTHERFerric Pyrophosphate and Zinc Sulfate
Rice fortified with Ferric Pyrophosphate and Zinc Sulfate
OTHERFerric Pyrophosphate
Rice fortified with Ferric Pyrophosphate
Sponsors
PATH
Swiss Federal Institute of Technology
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Female * Serum Ferritin Level \< 15 µg/L * Body weight \<65 kg * Signed informed consent 4. Body Mass Index in the range of 18.5 to 25
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in the isotopic ratio of iron in blood at week 2 | baseline, 2 weeks | The change in the isotopic ratio of iron will be measured after the administration of test meal including iron isotopes. |
| Change from week 2 in the isotopic ratio of iron in blood at week 4 | 2 weeks, 4 weeks | The change in the isotopic ratio of iron will be measured after the administration of test meal including iron isotopes. |
| Change from week 4 in the isotopic ratio of iron in blood at week 6 | 4 weeks, 6 weeks | The change in the isotopic ratio of iron will be measured after the administration of test meal including iron isotopes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Haemoglobin | baseline, 16th, 30th and 44th day | 14 or 15 days after each meal administration and at baseline |
| Plasma Ferritin | baseline, 16th, 30th and 44th day | 14 or 15 days after each meal administration and at baseline |
| C reactive protein | baseline, 16th, 30th and 44th day | 14 or 15 days after each meal administration and at baseline |
Countries
Switzerland
Outcome results
None listed