Ischemia Preconditioning, Ischemia-reperfusion, Vascular Surgery
Conditions
Brief summary
Open surgery for aneurysmal aortic disease can lead to cardiac, renal, pulmonary or muscular complications, essentially due to the aortic clamping. Ischemic preconditioning can be useful in order to decrease these complications. The investigators would like to use an ischemic preconditioning protocol during open surgery of aortic aneurysm in order to decrease these complications.
Interventions
PROCEDUREIschemic preconditioning during aortic clamping
Ischemic preconditioning during aortic clamping
PROCEDUREProcedure/Surgery: usual surgery
Procedure/Surgery: usual surgery
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients with an aortic aneurysm requiring open surgery (with no possibility of endovascular surgery) * Patients who received clear information, with signed consent * Patients 18 to 85 years
Exclusion criteria
* Patients under guardianship * No possibility to give the patients clear information (comprehension difficulties, emergency surgery) * Pregnancy, lactation * Hemodialysis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial damage measured by troponin level > 0.4 microgr/L (day 1) | Day 1 | Myocardial damage measured by Troponin I level \> 0.4 microg/L |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Renal damage | Day 0, day 1, day 3 or day 5. | Renal damage measured with Post-operative Creatinin clearance \< 50% of Pre-operative creatinin clearance |
| Muscle weakness | Day 0, day 1, day 3 or day 5 | Muscle weakness measured by Creatine phospho Kinase \> 200 UI/L |
| Myocardial damage measured by troponin level > 0.4 microgr/L | Day 0, 3, or 5 | — |
Countries
France
Outcome results
None listed