Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02253784

Enrollment

Registered

2014-10-01

Start date

2014-10-31

Completion date

2017-10-30

Last updated

2017-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia, Pain, Postoperative

Brief summary

The addition of dexamethasone (DxaM) to local anesthetic may significantly prolong the duration of a block in total knee arthroplasty. The aim of this study is to determine whether this is a systemic or local effect.

Interventions

DRUGDexamethasone

DRUGBupivacaine

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Pre-surgical total knee arthroplasty patients

Exclusion criteria

* Skin infection near block site * Allergy to local anesthetics * Peripheral neuropathy * Proven opioid dependency * Coagulopathy * Dementia

Design outcomes

Primary

Measure	Time frame	Description
Efficacy Perineural DxaM	One day	Duration of motor and sensory block

Secondary

Measure	Time frame	Description
Efficacy of Systemic DxaM	One day	Duration of motor and sensory block

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026