Neovascular (Wet) Age-related Macular Degeneration (AMD)
Conditions
Keywords
AMD, OCT, Angiography, Macular degeneration
Brief summary
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. diagnose the presence of new blood vessels in wet age-related macular degeneration (AMD) 2. evaluate patients undergoing treatment for wet AMD 3. determine if reduced flow to the choroid is a risk factor for developing wet AMD.
Interventions
DEVICEOptical Coherence Tomography
Sponsors
Oregon Health and Science University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
(Groups with wet AMD): * Adults aged 50 and older with clinical findings of treatment-naïve (never treated) neovascular AMD with active new blood vessel growth confirmed by clinical testing will be considered Inclusion Criteria (Group with healthy eyes) * No evidence of retinal disease * Refractive error greater than +3.00 diopters or -7.00 diopters (glasses Rx) * No recent eye surgery in the last 4 months * No significant cataract to interfere with the quality of the imaging
Exclusion criteria
(All Groups): * Inability to give informed consent * Significant kidney disease * Blood pressure greater than 180/110 * Previous macular laser treatment * Inability to maintain stable fixation during OCT imaging * Visual acuity worse than 20/200
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measure of choroidal neovascular (CNV) vessel area in mm2 | 1 year |
| Measure of CNV membrane area in mm2 | 1 year |
| Measure of CNV length density in mm | 1 year |
| Measure of retinal fluid volume in mm3 | 1 year |
| Measure of drusen area in mm2 | 3 years |
Countries
United States
Contacts
Primary ContactGeorge Pacheco, COA
Backup ContactDenny Romfh, OD
Outcome results
None listed