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Efficacy of Intravenous Naproksen Sodium+Codein and Paracetamol+Codein on Postoperative Pain on Postoperative Pain

Efficacy of Intravenous Naproksen Sodium+Codein and Paracetamol+Codein on Postoperative Pain and Contramal Consumption After a Lumbar Disk Surgery

Status
UNKNOWN
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02252614
Enrollment
75
Registered
2014-09-30
Start date
2014-09-30
Completion date
2014-12-31
Last updated
2014-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain, PCA Contramal Consumption

Keywords

naproxen sodium+codein, paracetamol+codein,lumbar disc surgery

Brief summary

Comparition the analgesic effects of intravenous naproksen sodyum+codein with that of paracetamol+codein on postoperative pain and contramal consumption during the first 24 hour after a lumbar disk surgery.

Detailed description

Patients were treated using patient-controlled analgesia with contramal for 24 hours after a lumbar disk surgery and randomized to receive IV naproksen sodium+codein, paracetamol+codein or isotonic saline (placebo). The primary endpoint was pain intensity measured by the visual analogue scale, and secondary endpoints were contramal consumption and related side effects.

Interventions

DRUGnaproxen sodium codein

Pain intensity, contramal consumption

DRUGparacetamol codein

Pain intensity, contramal consumption

DRUGPlacebo

Pain intensity, contramal consumption

Sponsors

Diskapi Yildirim Beyazit Education and Research Hospital
Lead SponsorOTHER_GOV

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
16 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

* American Society of Anesthesiologists 1 or 2 status patients scheduled for elective lumbar disk surgery under general anesthesia

Exclusion criteria

* Patients, known allergies to any of the drugs used in this study * eptic ulcer disease, hepatic and renal dysfunction, emergency surgery, or inability to provide informed consent (eg, mental disorders)

Design outcomes

Primary

MeasureTime frame
Pain intensity, contramal consumptionPostoperative 24 hour

Secondary

MeasureTime frame
side effects, nausa, vomitingpostoperative 24 hour

Contacts

Primary ContactReyhan Polat, MD
reyhanp9@gmail.com+905326734310

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026