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Combined Effect of Dexamethasone and Paracetamol for Postoperative Sore Throat

Combined Effect of Preoperative Dexamethasone and Intraoperative Paracetamol on Postoperative Sore Throat for Patients Undergoing Urologic Surgery

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02252419
Enrollment
242
Registered
2014-09-30
Start date
2014-10-31
Completion date
2015-03-31
Last updated
2014-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pharyngitis

Keywords

Postoperative Period, Anesthesia, General, Intubation, Intratracheal, Dexamethasone, Acetaminophen

Brief summary

The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.

Detailed description

The postoperative sore throat is a common complication after the general anesthesia which decreases the quality of life. Dexamethasone is known to effective for the prevention of postoperative sore throat. The combined effect of the dexamethasone and paracetamol for postoperative sore throat, however, is not investigated. The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.

Interventions

DRUGDexamethasone

Dexamethasone will be administered.

DRUGParacetamol

Paracetamol will be administered.

Sponsors

Seoul National University Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* Patients scheduled for urologic surgery under general anesthesia * ASA I-III

Exclusion criteria

* Patients with recent sore throat * Patients with neck surgery * Patients with anticipated difficult airway * Patients with Mallampati grade 3 * Patients with severe cardiovascular or pulmonary disease * Patients with allergic history to dexamethasone or paracetamol * Patients with liver function disorder * Patients with liver disease

Design outcomes

Primary

MeasureTime frameDescription
Postoperative sore throat1 hour postoperativelyPostoperative sore throat after 1 hour postoperatively will be measured (0:none, 1:mild, 2:moderate, 3:severe)

Secondary

MeasureTime frameDescription
Postoperative pain0, 1, 6, 24 hour postoperativelyPostoperative pain after 0, 1, 6, 24 hour postoperatively will be measured (11 points, 0:none, 10:worst imaginable).
Nausea0, 1, 6, 24 hour postoperativelyNausea will be measured at 0, 1, 6 and 24 hour postoperatively.
Vomiting0, 1, 6, 24 hour postoperativelyVomiting will be measured at 0, 1, 6 and 24 hour postoperatively.
Somnolence0, 1, 6, 24 hour postoperativelySomnolence will be measured at 0, 1, 6 and 24 hour postoperatively.
Shivering0, 1, 6, 24 hour postoperativelyShivering will be measured at 0, 1, 6 and 24 hour postoperatively.
Postoperative sore throat degree0, 1, 6, 24 hour postoperativelyPostoperative sore throat degree after 0, 1, 6, 24 hour postoperatively will be measured (11 points, 0:none, 10:worst imaginable).
Hoarseness0, 1, 6, 24 hour postoperativelyHoarseness will be measured at 0, 1, 6 and 24 hour postoperatively.
Dysphagia0, 1, 6, 24 hour postoperativelyDysphagia will be measured at 0, 1, 6 and 24 hour postoperatively.
Analgesics0, 1, 6, 24 hour postoperativelyAnalgesics usage will be measured at 0, 1, 6 and 24 hour postoperatively.
Postoperative sore throat0, 6, 24 hour postoperativelyPostoperative sore throat after 0, 6, 24 hour postoperatively will be measured (0:none, 1:mild, 2:moderate, 3:severe)
Headache0, 1, 6, 24 hour postoperativelyHeadache will be measured at 0, 1, 6 and 24 hour postoperatively.

Countries

South Korea

Contacts

Primary ContactHyun-Chang Kim, MD
onidori1979@gmail.com82-10-2886-2876

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026