Study on Abnormal Dopamine Synthesis and Connectivity According to the Antipsychotic Treatment Response in Schizophrenia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02248987

Enrollment

Registered

2014-09-25

Start date

2014-05-31

Completion date

2016-05-31

Last updated

2019-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Brief summary

The purpose of this study is to evaluate abnormal dopamine synthesis and connectivity according to the antipsychotic treatment response in schizophrenia.

Interventions

OTHERpatients treated with antipsychotics

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

20 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* diagnosis of schizophrenia * clinically stable state

Exclusion criteria

* history of previous head injury, epileptic disorder, other medical comorbidity * substance abuse/dependence

Design outcomes

Primary

Measure	Time frame
Striatal [18F]-DOPA uptake measured using positron emission tomographic 18F-dopa imaging.	within 2 weeks from enrollment

Secondary

Measure	Time frame
neurocognitive function test	within 2 weeks from enrollment
resting state functional magnetic resonance imaging	within 2 weeks from enrollment
diffusion tensor imaging	within 2 weeks from enrollment
clinical measure including Positive and Negative Syndrome Scale	within 2 weeks from enrollment

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026