Childhood Cancer Survivors Treated With Abdominal Radiation
Conditions
Keywords
Diabetes Risk, 14-202
Brief summary
The purpose of this study is to better understand the risk factors and causes of diabetes in people who received radiation to the abdomen as children. The investigators hope this information will allow them to improve how they screen people at risk for diabetes and how they treat patients in the future.
Interventions
None listed
Sponsors
Memorial Sloan Kettering Cancer Center
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Diagnosis of childhood cancer between 0-21 years of age * Prior treatment with abdominal radiation at MSKCC * Two or more years from completion of therapy * Records of cancer diagnosis and treatment (including radiation records) available
Exclusion criteria
* Known diagnosis of diabetes * Previous treatment with any radiation impacting the brain (cranial radiation, craniospinal radiation, total body irradiation) * Neurocognitive deficits that impair ability to give informed consent or assent * Patients predicted to have difficult intravenous access, who will likely require multiple venipuncture attempts
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| characterize β cell function | 2 years | we will be able to estimate the proportion of patients with abnormalities of insulin sensitivity or β cell function, as assessed by the OGTT, to within ± 0.14. |
| insulin sensitivity | 2 years | we will be able to estimate the proportion of patients with abnormalities of insulin sensitivity or β cell function, as assessed by the OGTT, to within ± 0.14. |
Countries
United States
Outcome results
None listed