Telomere Length and Other Parameters of Telomere Dysfunction in PSC and Colitis

Primary Sclerosing Cholangitis Telomere Length

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02247622

Enrollment

Registered

2014-09-25

Start date

2012-02-29

Completion date

2014-09-30

Last updated

2014-09-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Bowel Disease, Primary Sclerosing Cholangitis

Keywords

telomeres, PSC

Brief summary

PSC is a chronic cholestatic disorder. The investigators intend to study some telomere parameters and telomere length in order to predict a premalignant state.

Detailed description

Primary sclerosing cholangitis (PSC) and colitis are chronic inflammatory disorders with malignant potential. Telomerase is an enzyme complex that lengthens telomeres and has enhanced expression in numerous malignancies. In this study, we evaluated the telomerase gene copy number, telomere length, cells in senescence, aneuploidy and additional parameters of telomere dysfunction from peripheral blood lymphocytes of patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* informed consent * documented PSC and inflammatory bowel disease

Exclusion criteria

* under 18 years, above 80 y * known active malignancy * decompensated cirrhosis * patients who cannot sign informed consent

Design outcomes

Primary

Measure	Time frame
Telomere length	1.5 years

Secondary

Measure	Time frame
number of cells with increased telomerase RNA component (TERC) expression	1.5 years

Countries

Israel

Contacts

Primary ContactIdo Laish, MD

ido.laish@gmail.com+972-549477261

Outcome results