Ovarian Malignancy Incidence in Moderate Risk Women With Low CA 125

Ovarian Malignancy Incidence in Premenopausal Women Who Were at Moderate Risk for Malignancy by Risk of Malignancy Index With Low CA 125.(Retrospective Study)

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02247323

Acronym

CA125

Enrollment

200

Registered

2014-09-25

Start date

2016-01-31

Completion date

2021-12-31

Last updated

2021-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ovarian Cancer

Brief summary

The investigators are assessing the incidence of ovarian cancer in premenopausal women who were at moderate risk of malignancy with low CA125.

Detailed description

About 10% of premenopausal women may have a surgery for ovarian masses. In premenopausal women the incidence of ovarian malignancy is 1:1000 in case of symptomatic ovarian cyst.1 CA125 is unreliable in differentiating benign from malignant ovarian mass in premenopausal women due to many false positive results and reduced specificity.1 pelvic vaginal ultrasonography is the most effective tool in evaluating ovarian masses due to increased sensitivity over abdominal US.1 An estimation of risk of malignancy index is essential in evaluating an ovarian mass.26 /2 Risk of malignancy index combines presurgical features serum including CA125, menopausal status and ultrasound findings. RMI=Ux Mx CA125 in which each feature takes a score and after calculation score less than 25 is mild, from 25-250 moderate and more than 250 has a severe risk of malignancy needing oncologist.44/3

Interventions

OTHERRisk of malignancy index

Calculation of RMI before sugery.

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

45 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Women with complex ovarian cyst * Abdominal pain * Menometrorrhagia

Exclusion criteria

* Significant weight loss * Cachexia * History of ovarian or other malignancy * Family history of ovarian Cancer

Design outcomes

Primary

Measure	Time frame	Description
Incidence of ovarian malignancy	one year	Calculation of number of women who had ovarian cancer after an operation in moderate risk

Countries

Egypt

Contacts

Primary ContactNesreen A Shehata, MD

nesoomar@yahoo.com00201227866337

Backup ContactAbdelgany M Hassan, MD

abdelgany2@gmail.com00201017801604

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026