Malnutrition
Conditions
Keywords
Children and adolescents, Cancer, Malnutrition, BMI percentile, BMI-SDS
Brief summary
The main objective of this study was the assessment of the nutritional status of children and adolescents aged between 0-18 with malignancies based on BMI percentiles and standard deviation scores, at diagnosis, during treatment and during a period of two years after the end of therapy.
Detailed description
Children and adolescents suffering from malignancies often show malnutrition. Malnutrition, defined as a deficiency or an excess of energy, is associated with an increased risk of comorbidities, reduced survival rates, higher relapse rates, and worse treatment response. The present retrospective study assessed the nutritional status of children and adolescents, suffering from nine different kinds of cancer, based on BMI percentiles and standard deviation scores. Anthropometric data were recorded from clinical charts and an assessment of the nutritional status was made at the beginning of treatment, during the course of therapy and during a follow-up period of two years. The influence of treatment-related characteristics, the duration of therapy, and the occurrence of a relapse or progress during therapy on the nutritional status were examined.
Interventions
None listed
Sponsors
Olgahospital Stuttgart
University of Hohenheim
Study design
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* children and adolescents treated at the Olgahospital Stuttgart for one of the nine different cancer types * treated according to a study protocol of the Society of Pediatric Oncology and Hematology (GPOH), with modifications only allowed within the therapeutic protocol * time period between diagnosis and start of treatment less than 28 days * age younger than 18
Exclusion criteria
* severe underlying disease, which exerts a strong influence on weight and/or height * patients whose clinical record does not state any weight and/or height * diseases which are not considered as malignant because of the state or biology
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in nutritional status during treatment | Every month during the treatment period (average treatment period 11 months) | To assess the nutritional status height and weight were recorded from patient charts to calculate the BMI percentile and the BMI-SDS |
| Nutritional status at diagnosis | Within the month of diagnosis | To assess the nutritional status height and weight were recorded from patient charts to calculate the BMI percentile (Body Mass Index percentile) and the BMI-SDS (Body Mass Index-Standard Deviation Score) |
| Change in nutritional status during follow-up | Once in a period of three months during two years follow-up | To assess the nutritional status height and weight were recorded from patient chart to calculate the BMI percentile and the BMI-SDS |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of nutritional interventions | Patients were followed for the incidence of a nutritional intervention within the treatment period (average treatment period 11 months) | Application of parenteral nutrition or gastric tube (yes/no), recorded from patient chart |
| Infection | Patients were followed for the occurence of an infection within the treatment period (average treatment period 11 months) | Occurence of an infection (yes/no), recorded from patient chart |
| Fever | Patients were followed for the occurence of fever within the treatment period (average treatment period 11 months) | Occurence of fever (yes/no), recorded from patient chart |
| Administration of antibiotics | Patients were followed for the occurence of an administration of antibiotics within the treatment period (average treatment period 11 months) | Administration of antibiotics (yes/no), recorded from patient chart |
| Diarrhea | Patients were followed for the occurence of diarrhea within the treatment period (average treatment period 11 months) | Occurence of diarrhea (yes/no), recorded from patient chart |
| Clinical picture | Within the month of diagnosis | Kind of cancer (lymphoma, germ cell tumor, nephroblastoma, soft tissue sarcoma, neuroblastoma, Ewing sarcoma, brain tumor, acute lymphoblastic leukemia (ALL)/acute myeloid leukemia (AML)), recorded from patient chart |
| Nausea | Patients were followed for the occurence of nausea within the treatment period (average treatment period 11 months) | Occurence of nausea (yes/no), recorded from patient chart |
| Constipation | Patients were followed for the occurence of constipation within the treatment period (average treatment period 11 months) | Occurence of constipation (yes/no), recorded from patient chart |
| Relapse/Progress | Patients were followed for the occurence of a relapse/progress within the treatment period (average treatment period 11 months) and follow-up (two years) | Occurence of a relapse/progress (yes/no), recorded from patient chart |
| Kind of treatment | Patients were followed for the kind of treatment they received wihin the treatment period (average treatment period 11 months) | Kind of treatment (chemotherapy, operation, Radiation), recorded from Patient chart |
| Mucositis | Patients were followed for the occurence of mucositis within the treatment period (average treatment period 11 months) | Occurence of mucositis (yes/no),recorded from patient chart |
| Age (years) | Within the month of diagnosis | Age in years, recorded from patient chart |
| Treatment period (months) | Patients were followed for the duration of their treatment period. Average treatment period 11 months | Time from start until the end of treatment, recorded from patient chart |
Outcome results
None listed