Cannabis Users
Conditions
Brief summary
There is an association between intracranial arterial stenosis and ischemic stroke in young adults. The aim of this study is to evaluate the prevalence of intracranial arterial stenosis in asymptomatic regular resin of cannabis users in comparison with control subjects.
Interventions
OTHERCerebral MRI and MRA
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* regular resin of cannabis users
Exclusion criteria
* taking vasoactive medications * taking other illicit drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of intracranial arterial stenosis on cerebral MRA | 3 months | Rate on cerebral MRA the presence of cerebral Intracranial Arterial Stenosis segmental narrowing defined by at least two intra-cranial arteries compared with a cohort of non cannabis controls subjects. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| -Silent ischemic stroke on cerebral MRI | 3 months | Evaluate on cerebral MRI the presence of sequelae of ischemic stroke defined by a parenchymal hyperintensity in a vascular territory defined on a T2 sequence. |
| -new intracranial arterial stenosis at 3 month follow-up | 3 months | Evaluate a cerebral MRA at 3 months the presence of new intracranial stenosis among cannabis users, according to the prosecution or stopping use |
| -Reversibility of intracranial arterial stenosis at 3 month follow-up | 3 months | Evaluate on cerebral MRA at 3 months reversibility stenosis present at T0 in cannabis users having stopped their consumption |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORValerie Wolff, MD
University Hospital, Strasbourg, France
Outcome results
None listed