Limb Girdle Muscular Dystrophy
Conditions
Keywords
Limb Girdle Muscular Dystrophy, Autologous Bone Marrow Mononuclear cell therapy, Stem Cell
Brief summary
The purpose of this study was to study the effect of stem cell therapy on Limb Girdle Muscular Dystrophy patients.
Interventions
BIOLOGICALStem Cell
Sponsors
Neurogen Brain and Spine Institute
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* age group of 15 years-60 years * limb girdle muscular dystrophy diagnosed on the basis of clinical presentation * Electromyographic and Nerve Conduction velocity findings
Exclusion criteria
* presence of respiratory distress * presence of acute infections such as Human Immunodeficient Virus/Hepatitis B Virus/Hepatitis C Virus * malignancies * acute medical conditions such as respiratory infection, fever, hemoglobin less than 8, bleeding tendency, bone marrow disorder, left ventricular ejection fraction \< 30% * pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Functional Independence Measure (FIM) scale | 1 year | Functional Independence Measure scale assesses the patients ability to carry out activities of daily living. At the follow up of 1 year, every patient in this study will be reevaluated on this scale. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Manual Muscle Testing (MMT) | 1 year | Manual muscle testing is a procedure for the evaluation of the function and strength of individual muscles and muscle groups based on the effective performance of a movement in relation to the forces of gravity and manual resistance. On the follow up after 1 year, every patient will be reassessed on MMT to record changes in their muscle strength after stem cell therapy. |
Countries
India
Outcome results
None listed