Dairy Intake and Brain Health in Aging

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02245035

Enrollment

Registered

2014-09-19

Start date

2011-10-31

Completion date

2014-12-31

Last updated

2017-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aged Healthy Volunteer

Keywords

Glutathione, Dairy consumption, Brain, Humans

Brief summary

The purpose of this study is to learn if dairy food consumption may help brain health in aging by protecting nerve cells from oxidative damage.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

1. Males and females between 60-85 years of age. 2. Good general health with no concomitant diseases, which would be expected to interfere with the study 3. BMI range 20-35 kg/m2

Exclusion criteria

1. Presence of any central neurological disease with the potential to impair cognition(e.g., brain tumor, stroke, epilepsy, motor neuron disease, multiple sclerosis, Alzheimer disease, Parkinson's disease) or prior major head trauma with loss of consciousness 2. Presence of an active unstable and life-threatening systemic illness (e.g., cancer) 3. Presence of major psychiatric disorder within the past 3 years including depression, anxiety, and alcohol (over 3 drinks per day or total of 18 per week) or drug abuse (DSM-IV criteria; Geriatric Depression Score\>6) 4. Presence of diabetes mellitus (defined as a clinical diagnosis or use of an anti-diabetic agent) and metabolic syndrome 5. Use of psychoactive and investigational medications 6. Subjects with MRI contraindications such as pacemaker, aneurysm clips, artificial heart valves, metal fragments, foreign objects or claustrophobia. All subjects subjects will receive a structural MRI as part of this study. Individuals with evidence of infection, infarction, neoplasm or other lesions will be excluded. Individuals found to have abnormalities in their structural MRI will be referred to their primary physician for further evaluation and management. 7. Pregnancy 8. Special diet regimens such as lactose free or vegan

Design outcomes

Primary

Measure	Time frame
Cerebral glutathione (GSH) levels measured by magnetic resonance spectroscopy (MRS)	Baseline
Dietary dairy food intake measured using 7-day diet recording	1 week, prior to MRS scan

Countries

United States

Outcome results