Heart Rate and Cardiovascular Diseases Prognosis in People With Stable Coronary Artery Disease

Association of Heart Rate With Cardiovascular Disease Prognosis of Patients With Stable Coronary Artery Disease: A CALIBER Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02244853

Enrollment

51703

Registered

2014-09-19

Start date

2013-09-30

Completion date

2014-12-31

Last updated

2014-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Bleeding, Coronary Heart Disease, Death, Sudden, Cardiac, Heart Failure, Myocardial Infarction, Peripheral Arterial Disease, Stable Angina, Stroke

Brief summary

The Cardiovascular disease research using Linked Bespoke studies and Electronic Records (CALIBER) e-health database was the data resource for this study. CALIBER links patient records from four different data sources: Clinical Practice Research Database (CPRD), MINAP (Myocardial Ischaemia National Audit Project registry) Hospital Episodes Statistics (HES), the Office for National Statistics (ONS).

Detailed description

This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Healthy volunteers

Yes

Inclusion criteria

* Aged \>=30 years at study entry -\>=1 year registration prior to the 'index date'

Exclusion criteria

* Free from previous atherosclerotic events * No heart rate measurement after their 'index date' of eligibility to entry the study

Design outcomes

Primary

Measure	Time frame	Description
Risk of cardiovascular diseases in patients with low and high heart rate and stable coronary artery disease	expected average of 3 years	Participants were followed until their first cardiovascular or complication event after their studyentry and after at least one previous cardiovascular event. Hazard ratios will be presenting associations between heart rate (analysed as quintiles and as continuous per 10bpm) and 8 different cardiovascular diseases (including mortality outcomes, complications such as bleeding events and composite cerebrovascular and coronary heart disease endpoints).

Countries

United Kingdom

Outcome results