Hyperalgesia, Ibuprofen, Pain, Postoperative, Remifentanil
Conditions
Brief summary
Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia
Interventions
high dose remifentanil
DRUGIbuprofen
intravenous ibuprofen
low dose remifentanil
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients scheduled for elective pancreaticoduodenectomy
Exclusion criteria
* Patients with chronic pain * Patients with psychiatric disease * Patients with nonsteroidal antiinflammatory drugs allergy * Patients with renail dysfunction * History of drug addiction * Pregnant patient * Inability to use a PCA device
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cumulative morphine consumption | postoperative 48 hours | cumulative patient-controlled analgesia (PCA) morphine consumption |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain score | postoperative 1, 3, 6,12, 24, 48 hours Pain score | visual analogue scale |
Countries
South Korea
Outcome results
None listed