Female Breast Carcinoma
Conditions
Brief summary
The purpose of study is to investigate if yoga exercise improve life quality and immune status in breast cancer patients after complete treatment (including surgery and / or radiotherapy and / or chemotherapy)
Detailed description
It is well-known that exercise promote immune regulation for better life quality. However, the mechanism for better immunity and life quality is not clear. We postulate that Ayurveda yoga might benefit breast cancer women with completion of operation and/or chemotherapy and radiotherapy. The benefits could be due to immune modulation, and improve health perception and life quality, and even potential decrease of cancer relapse. The study patients will do yoga twice a week for 12 weeks. The study primary endpoints are 1) to improve personal health perception, 2) to improve life quality and 3) to enhance human immunity. The study secondary endpoint will follow up the immunity changes 3 months after the intervention. We anticipate to reach the primary endpoints and to publish the primary results in one year, the secondary endpoint will complete in the second year.
Interventions
BEHAVIORALYoga exercise
Subjects will receive regular 90-minutes yoga classes twice a week for 3 months.
Sponsors
Chang Bing Show Chwan Memorial Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Able to attend yoga program weekly, and fill out inform consent. * Patients with breast cancer after complete treatment for at least 3 months (including surgery and / or radiotherapy and/or chemotherapy).
Exclusion criteria
* male * overweight * unable to do yoga exercise.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improve personal health and life quality | Change from baseline in personal health and life quality at 6 months. | Health and life quality will assessed by modified fatigue inventory and EORTC QLQ-C30 (version 3) at three different times: (1)baseline data: before yoga exercise, (2)outcome data: at 6 and 12 weeks post-test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Immune modulation | Change from baseline in human immunity at 3 months. | Lymphocytes will be extracted from peripheral blood for analyses of lymphocytes subpopulation (Th1/ Th2/ Treg/ Th17), polarization (T-bet/ Gata-3/ Foxp3/ RORrt) and its related cytokines (Th1: IL-12/ IFN-γ/ IL-27; Th2: IL-4/ IL-13/ IL-25; Th17: IL-17A/ IL-6/ IL-21; Treg: TGF/ IL-10. Saliva collection for analyses of cortisol and IL-6 at 3 different times: (1) baseline data: before yoga exercise, (2)outcome data: at 6 and 12 weeks post-test. |
Countries
Taiwan
Contacts
Primary ContactShin-Mae Wang, MD.
Backup ContactShu-Hui Yeh Yeh, PhD
Outcome results
None listed