Brain fMRT In Takotsubo Cardiomyopathy

Pilot Study: Central Nervous System and Hormonal Changes In Takotsubo Cardiomyopathy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02240056

Acronym

TAKINSULA

Enrollment

Registered

2014-09-15

Start date

2014-10-31

Completion date

2019-03-31

Last updated

2019-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Takotsubo Cardiomyopathy

Brief summary

Certain cardiac and neurologic diseases influence each other via a still poorly understood brain-heart axis. Subarachnoidal bleedings are well known to cause ECG alterations resembling those of myocardial infarction, along with a reduction of systolic myocardial function (neurogenic stunned myocardium). Alterations of the right insula region by a stroke or intracranial hemorrhage go along with a sympathetic activation (increased circulating catecholamine levels, tachycardia, arterial hypertension). In contrast, alterations of the left insula region often cause vagal reactions such as bradycardia, arterial hypotension. Takotsubo cardiomyopathy (TTC) is a just recently recognised subform of heart attacks, often caused by psychological or physical stress (death of a beloved one, divorce, job loss, infection, preoperative state). In more than 90% of cases, TTC affects postmenopausal women. Functional MRT enables imaging of activated brain regions, either without (resting state) or with specific stimuli. The investigators speculate that there is a specific involvement of the insula region during TTC.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

No minimum to 90 Years

Healthy volunteers

Inclusion criteria

* Postmenopausal females aged below 90 years * Informed written consent * TTC or NSTEMI / STEMI undergoing coronary angiography within 24 hours of symptom onset

Exclusion criteria

* Delayed coronary angiography (\> 24 hours after symptom onset) * Inability to perform rsfMRT within the first 72 hours after coronary angiography * Inability to communicate in German language * Contraindications for a MRT examination (including pacemaker, implantable cardioverter-defibrillator, mechanical heart valves, claustrophobia, severe adipositas) * Drug addiction, under guardianship * Inability to stick to the follow up examination

Design outcomes

Primary

Measure	Time frame
Changes in brain functional MRT (resting state, paradigma) in postmenopausal females suffering from TTC as compared to NSTEMI / STEMI postmenopausal female patients	Within the first 72h after diagnosis and after 4-8 weeks

Countries

Austria

Outcome results