Knee Osteoarthritis
Conditions
Keywords
Platelet rich plasma, Osteoarthritis of knee, Balance, Strength
Brief summary
Although few studies have showed beneficial effect of platelet rich plasma (PRP) for osteoarthritis of knee (OA knee), only one study applied randomized, control method and none of them has the objective measurements such as balance test or muscle strength which were reported as decrease in patients with OA knees. We assess the analgesic effect and the extent of improved muscle strength and balance after PRP in patients with OA knee.
Detailed description
Patients with bilateral OA knee will be enrolled and randomized into intervention and control knee. One dose of PRP is applied in the intervention knee and normal saline in control side. Outcome measurements included visual analog scale (VAS)、Lequesne's severity index、Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)、balance test (Biodex) and isokinetic strengthening test at different follow-up frame (2nd week, 1st month, 3rd month and 6th month after treatment).
Interventions
DRUGplatelet rich plasma
Platelet rich plasma (PRP) is a new and potential treatment for patients with kinds of musculoskeletal disorders.
DRUGNormal saline
The normal salin as the placebo intervention was injection in the other side of knee.
Sponsors
Yung-Tsan Wu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
35 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Age between 35 to 75 y/o. 2. Alert consciousness 3. Symptom of knee osteoarthritis persist at least 6 months and stage I or II scored by Ahlbäck grading system 4. The pain score measured by VAS at least 4 points
Exclusion criteria
1. Has received hyaluronic acid or steroid injection within 6 monts 2. Has received NSAIDs or steroid within one week 3. Tumor or metastasis surrounding the knee joint 4. Has received total knee replacement, major surgery in knee, rheumatoid arthritis 5. Patient who cant tolerance the balance or muscle strength test.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline of pain on 2nd week, 1st month, 3rd month and 6th month after PRP. | Pre-treatment, 2nd week, 1st month, 3rd month and 6th month after PRP. | Using the Visual analog scale (VAS) to measure the pain scale before treatment and multiple time frame after treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in severity of symptoms and functional status on 2nd week, 1st month, 3rd month and 6th month after treatment. | Pre-treatment, on 2nd week, 1st month, 3rd month and 6th month after treatment.. | Using the Lequesne's severity index to measure the symptoms and functional status before treatment and multiple time frame after treatment. |
| Change from baseline in balance function on 2nd week, 1st month, 3rd month and 6th month after treatment. | Pre-treatment, 2nd week, 1st month, 3rd month and 6th month after treatment. | Using the balance test (Biodex) to measure the balance function before treatment and multiple time frame after treatment. |
| Change from baseline in muscle strength of lower extremities on 2nd week, 1st month, 3rd month and 6th month after treatment. | Pre-treatment, 2nd week, 1st month, 3rd month and 6th month after treatment. | Using the isokinetic strengthening test to measure the muscle strength of lower extremities before treatment and multiple time frame after treatment. |
Countries
Taiwan
Outcome results
None listed