Detection of Brown Adipose Tissue by Magnetic Resonance Imaging

Assessment of MRI Accuracy for the Detection of Brown Adipose Tissue Using [18F]-2-fluoro-2-deoxy-D-glucose (Fluorodeoxyglucose) -PET as a Gold Standard

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02237872

Acronym

BAT_PET/MRI

Enrollment

Registered

2014-09-11

Start date

2015-01-20

Completion date

2015-08-27

Last updated

2025-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brown Adipose Tissue, Obesity

Keywords

Brown Adipose Tissue, MRI and PET detection of brown adipose tissue

Brief summary

The primary goal of this study is to assess the accuracy of conventional fat fraction proton MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using \[18F\]-2-fluoro-2-deoxy-D-glucose (fluorodeoxyglucose) -PET as gold standard. In this pilot study, MRI and PET imaging of BAT of healthy adult volunteers will be performed on a combined PET/MRI scanner under mild cold condition.

Detailed description

In the fight against obesity, brown adipose tissue (BAT) is considered to be the newest target. The hypothesis is that this tissue is partially responsible for the imbalance between energy intake and energy expenditure that keeps lean people lean and obese people obese. The detection of this tissue in adult humans represents an unmet need. BAT is difficult to detect and measurements of tissue fat fraction performed by magnetic resonance imaging have been proposed as a mean to differentiate the highly hydrated brown fat from the less hydrated white adipose tissue and from muscle. To this end, the objective of this study is to assess the accuracy of magnetic resonance fat fraction measurements for the detection of BAT volume in adult humans, while using PET with fluorodeoxyglucose as gold standard. For this study subjects will undergo a combined MRI/PET scan. The scans will be done during stimulation of thermogenic activity by mild cold exposure.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Each subject must be fully informed and have signed consent. * BMI \< 34 * Normal neurological and psychological development / able to give consent * Willingness to participate in this study

Exclusion criteria

* Subjects less than 18 years of age * Severe claustrophobia * Women who are pregnant, nursing an infant or planning to become pregnant in the next 30 days * People who have a condition that makes MRI unsafe for them (for example, cardiac pacemaker, epicardial pacemaker leads, cochlear implants, metal aneurysm clip, iron filings in your eyes or metal halo devices) * Have had radiation therapy or chemotherapy in the 2 months prior to PET scan * Subjects are taking medications that may interfere with BAT detection

Design outcomes

Primary

Measure	Time frame	Description
Average dice similarity coefficient	Up to 1 year after the imaging scan	The average dice similarity coefficient will be measured to assess the overlap between MRI and PET maps

Countries

United States

Outcome results